This report explains an investigation on development of fast mouth dissolve tablets of felodipine and comparison of efficiency of disintegrant functions of 3 classes of super disintegrants employing 3 different granulation techniques. In this study fast mouth dissolve tablets of felodipine were prepared using 3 classes of disintegrants like cross carmellose sodium (CCS), crosspovidone (CP) and sodium starch glycolate (SSG) employing 3 granulation techniques viz., wet granulation (WG), intra-extra granulation (IE) and direct compression (DC) techniques. 13 formulae with two levels of concentration of each superdisintegrants incorporated in the preparation of tablets by DC technique and constant concentration level of each superdisintegrant in the preparation of tablets by WG and IE technique. The granules were subjected for precompressional evaluation parameters like bulk density, tap density, and Carr�s index and the tablets were evaluated for postcompressional parameters such as hardness, friability, weight variation, in-vitro disintegration time and in-vitro dissolution study. The results obtained were within the acceptance limits. It was concluded that among the 3 disintegrants and granulation techniques, the tablets prepared with CCS as disintegrant employing with IE granulation technique were found to be superior with respect to disintegration and dissolution.
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